Genome resources provide a comprehensive catalog of genome features. Understanding how those components work together is key to understanding genome biology. Check out this post from the Saccharomyces Genome Database Blog:
As anyone who has tinkered with the inside of a living cell or looked at one of those daunting and overwhelming biochemistry poster knows, life is complicated. Like thousands of gears all interconnected in some vast steampunk machine, a cell has thousands of genes making thousands of proteins that come in a variety of flavors all interacting in overlapping, complicated ways to keep the cell alive. Toss in those important RNAs and a few other bells and whistles and you begin to understand why scientists have had to just focus in on individual parts of the machine to study.
Until now that is. In a new study out in Science led by University of Toronto Professors Brenda Andrews and Charles Boone, and Professor Chad Myers of the University of Minnesota-Twin Cities, Costanzo and coworkers were able to get a first approximation of how all those genes are connected in a yeast cell. And it is as complicated as you imagined.
This was a daunting undertaking that took over 15 years to pull off but it looks like it was well worth it. They have already learned an incredible amount and people will continue to learn more and more as scientists mine this treasure trove of data for a long time to come (Stay tuned for the data to be available here at SGD). This is the sort of study that will provide an invaluable reference guide that will keep giving year after year after year.