Version: 8.2.0Date: Wed Aug 27 2025
Category
nipi-3
(Caenorhabditis elegans)Gene
Name: No Induction of Peptide after Drechmeria Infection 3
Synonyms: K09A9.1, CELE_K09A9.1
Source: WB:WBGene00010700
Biotype: protein coding gene
Symbol: nipi-3 (Cel)
Symbol: nipi-3
Gene Synopsis: nipi-3 encodes a kinase similar to the human kinase Tribbles homolog 1; nipi-3 functions in the innate
Cross References: WB:nipi-3...nipi-3...nipi-3
NIPI-3 regulates the expression of C. elegans immune genes
(Caenorhabditis elegans)HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by WB
ID: WB:Microarray_Study.WBPaper00050515.ce.mr,
Tags: innate immune response
Summary: Many pathogens secrete toxins that target key host processes resulting in the activation of immune pathways. The secreted Pseudomonas aeruginosa toxin Exotoxin A (ToxA) disrupts intestinal protein synthesis which triggers the induction of a subset of P. aeruginosa-response genes in the nematode Caenorhabditis elegans. We found that losing one ToxA-induced C. elegans gene, the Tribbles pseudokinase ortholog nipi-3, results in hypersusceptibility to both P. aeruginosa and ToxA. We determined that NIPI-3 mediates the post-developmental expression of intestinal immune genes and proteins and primarily functions in parallel to known immune pathways, including p38 PMK-1 MAPK signaling. Here we present the microarray data that was used to determine that (1) nipi-3 regulates immune gene expression and that (2) nipi-3 and pmk-1 regulate non-overlapping gene sets consistent with them functioning in parallel. We used microarray analysis to identify the genes regulated by nipi-3 and pmk-1 at the L4 stage.
Symbol: NIPI-3 regulates the expression of C. elegans immune genes
Name: NIPI-3 regulates the expression of C. elegans immune genes...NIPI-3 regulates the expression of C. elegans immune genes
TRIB1
(Homo sapiens)Gene
Name: tribbles pseudokinase 1
Synonyms: GIG-2, tribbles-like protein 1, G-protein-coupled receptor-induced protein 2, SKIP1, phosphoprotein regulated by mitogenic pathways, C8FW, TRB1, GIG2, tribbles homolog 1, TRB-1, G-protein-coupled receptor-induced gene 2 protein, G-protein-coupled receptor induced protein
Source: HGNC:16891
Biotype: protein coding gene
Strict Orthology Symbols: nipi-3
trib3
(Danio rerio)Gene
Name: tribbles pseudokinase 3
Synonyms: zgc:76966
Source: ZFIN:ZDB-GENE-040426-2609
Biotype: protein coding gene
Strict Orthology Symbols: nipi-3
Trib1
(Rattus norvegicus)Gene
Name: tribbles pseudokinase 1
Synonyms: tribbles homolog 1 (Drosophila), G-protein-coupled receptor induced protein GIG2, Gig2, tribbles homolog 1
Source: RGD:621596
Biotype: protein coding gene
Strict Orthology Symbols: nipi-3
Trib2
(Rattus norvegicus)Gene
Name: tribbles pseudokinase 2
Synonyms: LOC313974, tribbles homolog 2 (Drosophila), LOC690207, similar to Tribbles homolog 2, LOC108351208, uncharacterized LOC108351208, tribbles homolog 2, RGD1564451, hypothetical protein LOC690207
Source: RGD:1564451
Biotype: protein coding gene
Strict Orthology Symbols: nipi-3
Trib3
(Rattus norvegicus)Gene
Name: tribbles pseudokinase 3
Synonyms: tribbles homolog 3 (Drosophila), neuronal cell death-inducible putative kinase, NIPK, kinase, Neuronal cell death Inducible Putative Kinase, tribbles homolog 3, LOC246273, TRB-3
Source: RGD:708432
Biotype: protein coding gene
Strict Orthology Symbols: nipi-3
Trib3
(Mus musculus)Gene
Name: tribbles pseudokinase 3
Synonyms: SKIP3, NIPK, Nipk, induced in fatty liver dystrophy 2, Trb3, Ifld2
Source: MGI:1345675
Biotype: protein coding gene
Strict Orthology Symbols: nipi-3
trbl
(Drosophila melanogaster)Gene
Name: tribbles
Synonyms: tribbles, tribble, trb, Tribbles, CG5408, Tribble, Trbl, Tribbless
Source: FB:FBgn0028978
Biotype: protein coding gene
Strict Orthology Symbols: nipi-3
trib1
(Xenopus tropicalis)Gene
Name: tribbles pseudokinase 1
Synonyms: tribbles, LOC108719410, trib1, skip1, trb1, c8fw, tribbles pseudokinase 1, gig2
Source: Xenbase:XB-GENE-956608
Biotype: gene
Strict Orthology Symbols: nipi-3
trib2
(Xenopus tropicalis)Gene
Name: tribbles pseudokinase 2
Synonyms: trib2, xtrb2, LOC108718251, Trb2, tribbles pseudokinase 2, c5fw
Source: Xenbase:XB-GENE-489426
Biotype: gene
Strict Orthology Symbols: nipi-3
ju1293
(Caenorhabditis elegans)Allele/Variant
Source: WB:WBVar02147575
Genes: nipi-3 (Cel)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Genes: nipi-3 (Cel)
IG544
(Caenorhabditis elegans)Model
Id: WB:WBStrain00021982
Synonyms: Not Available
Genes: nipi-3 (Cel)
IG342
(Caenorhabditis elegans)Model
Id: WB:WBStrain00021978
Synonyms: Not Available
Genes: nipi-3 (Cel)
IG1592
(Caenorhabditis elegans)Model
Id: WB:WBStrain00021991
Synonyms: Not Available
Genes: nipi-3 (Cel)
tm3373
(Caenorhabditis elegans)Allele/Variant
Source: WB:WBVar00252066
Genes: nipi-3 (Cel)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Genes: nipi-3 (Cel)
Gene Ontology
Source: GO:0031434
Synonyms:
- MAPKK binding
Branch: molecular function
Genes: nipi-3 (Cel)
Gene Ontology
Source: GO:0061760
Synonyms: Not Available
Branch: biological process
Genes: nipi-3 (Cel)
Gene Ontology
Source: GO:0050832
Synonyms:
- defence response to fungi
- defence response to fungus
Branch: biological process
Genes: nipi-3 (Cel)
Disease
Source: DOID:4194
Definition: A carbohydrate metabolic disorder that is characterized by blood glucose levels which cannot be maintained within the normal range.
Genes: nipi-3 (Cel)
Source: GO:0032436
Synonyms:
- activation of proteasomal ubiquitin-dependent protein catabolic process
- stimulation of proteasomal ubiquitin-dependent protein catabolic process
Branch: biological process
Genes: nipi-3 (Cel)
Gene Ontology
Source: GO:0050830
Synonyms:
- Gram-positive antibacterial peptide activity
- defence response to Gram-positive bacteria
Branch: biological process
Genes: nipi-3 (Cel)
Gene Ontology
Source: GO:0050829
Synonyms:
- Gram-negative antibacterial peptide activity
- defence response to Gram-negative bacteria
Branch: biological process
Genes: nipi-3 (Cel)
Gene Ontology
Source: GO:0140297
Synonyms:
- activating transcription factor binding
- repressing transcription factor binding
Branch: molecular function
Genes: nipi-3 (Cel)
Gene Ontology
Source: GO:0010629
Synonyms:
- gene silencing
Branch: biological process
Genes: nipi-3 (Cel)
Gene Ontology
Source: GO:0010468
Synonyms:
- gene regulation
- regulation of gene product expression
Branch: biological process
Genes: nipi-3 (Cel)
Gene Ontology
Source: GO:0010628
Synonyms: Not Available
Branch: biological process
Genes: nipi-3 (Cel)
Gene Ontology
Source: GO:0004672
Synonyms:
- protamine kinase activity
Branch: molecular function
Genes: nipi-3 (Cel)
(WBcel235)X:15608081G>A
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.15608081G>A
Genes: nipi-3 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant
Diseases: Not Available
Variant Name: (WBcel235)X:15608081G>A
Gene Cross References: nipi-3
(WBcel235)X:15608841G>A
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.15608841G>A
Genes: nipi-3 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)X:15608841G>A
Gene Cross References: nipi-3
(WBcel235)X:15608914C>T
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.15608914C>T
Genes: nipi-3 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)X:15608914C>T
Gene Cross References: nipi-3
(WBcel235)X:15608930C>T
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.15608930C>T
Genes: nipi-3 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: splice_region_variant, intron_variant
Diseases: Not Available
Variant Name: (WBcel235)X:15608930C>T
Gene Cross References: nipi-3
(WBcel235)X:15609070G>A
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.15609070G>A
Genes: nipi-3 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant
Diseases: Not Available
Variant Name: (WBcel235)X:15609070G>A
Gene Cross References: nipi-3
(WBcel235)X:15609870G>A
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.15609870G>A
Genes: nipi-3 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant
Diseases: Not Available
Variant Name: (WBcel235)X:15609870G>A
Gene Cross References: nipi-3
(WBcel235)X:15610051T>C
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.15610051T>C
Genes: nipi-3 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: synonymous_variant
Diseases: Not Available
Variant Name: (WBcel235)X:15610051T>C
Gene Cross References: nipi-3
(WBcel235)X:15608918C>T
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.15608918C>T
Genes: nipi-3 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)X:15608918C>T
Gene Cross References: nipi-3
(WBcel235)X:15609922C>T
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.15609922C>T
Genes: nipi-3 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: synonymous_variant
Diseases: Not Available
Variant Name: (WBcel235)X:15609922C>T
Gene Cross References: nipi-3
(WBcel235)X:15608363G>A
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.15608363G>A
Genes: nipi-3 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant
Diseases: Not Available
Variant Name: (WBcel235)X:15608363G>A
Gene Cross References: nipi-3
(WBcel235)X:15608614G>A
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.15608614G>A
Genes: nipi-3 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant
Diseases: Not Available
Variant Name: (WBcel235)X:15608614G>A
Gene Cross References: nipi-3
(WBcel235)X:15610361T>A
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.15610361T>A
Genes: nipi-3 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: 3_prime_UTR_variant
Diseases: Not Available
Variant Name: (WBcel235)X:15610361T>A
Gene Cross References: nipi-3
(WBcel235)X:15609276G>A
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.15609276G>A
Genes: nipi-3 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant
Diseases: Not Available
Variant Name: (WBcel235)X:15609276G>A
Gene Cross References: nipi-3
(WBcel235)X:15609303G>C
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.15609303G>C
Genes: nipi-3 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)X:15609303G>C
Gene Cross References: nipi-3
fr148
(Caenorhabditis elegans)Allele/Variant
Source: WB:WBVar02147574
Genes: nipi-3 (Cel)
Synonyms: Not Available
Variant Type: deletion
Molecular Consequence: 5_prime_UTR_variant, coding_sequence_variant
Diseases: Not Available
Variant Name: Not Available
Genes: nipi-3 (Cel)
fr4
(Caenorhabditis elegans)Allele/Variant
Source: WB:WBVar00145345
Genes: nipi-3 (Cel)
Synonyms: Not Available
Variant Type: point_mutation
Molecular Consequence: missense_variant
Diseases: Not Available
Variant Name: Not Available
Genes: nipi-3 (Cel)
(WBcel235)X:15607994C>T
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.15607994C>T
Genes: nipi-3 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant
Diseases: Not Available
Variant Name: (WBcel235)X:15607994C>T
Gene Cross References: nipi-3
(WBcel235)X:15608540G>T
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.15608540G>T
Genes: nipi-3 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant
Diseases: Not Available
Variant Name: (WBcel235)X:15608540G>T
Gene Cross References: nipi-3
(WBcel235)X:15609937C>T
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.15609937C>T
Genes: nipi-3 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: synonymous_variant
Diseases: Not Available
Variant Name: (WBcel235)X:15609937C>T
Gene Cross References: nipi-3
(WBcel235)X:15609938C>T
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.15609938C>T
Genes: nipi-3 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: stop_gained
Diseases: Not Available
Variant Name: (WBcel235)X:15609938C>T
Gene Cross References: nipi-3
(WBcel235)X:15608848A>C
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.15608848A>C
Genes: nipi-3 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)X:15608848A>C
Gene Cross References: nipi-3
(WBcel235)X:15608971G>A
(Caenorhabditis elegans)Allele/Variant
Source: NC_003284.9:g.15608971G>A
Genes: nipi-3 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant
Diseases: Not Available
Variant Name: (WBcel235)X:15608971G>A
Gene Cross References: nipi-3